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KMID : 0369819940240040289
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Jorunal of Korean Pharmaceutical Sciences
1994 Volume.24 No. 4 p.289 ~ p.295
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Drug Interaction between Phenytoin and Verapamil in Rabbits
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최준식/Choi JS
이일권/Lee IK
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Abstract
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Pharmacokinetic drug interaction between phenytoin and verapamil was investigated following i.v. administration of two drugs concomitantly to rabbits. Verapamil was coadministered with phenytoin (5 mg/kg) to rabbits at the doses of 0.5,1 and 2 mg/kg, respectively. Plasma concentration and AUC of phenytoin were increased significantly, but volume of distribution and total body clearance were decreased significantly (p<0.05) at doses of 1mg and 2mg/kg of verapamil, respectively. From the results of this experiment, it is desirable that dosage regimen of phenytoin should be adjusted and that therapeutic drug monitoring should be performed for reduction of side or toxic effect when phenytoin should be administered with verapamil in clinical practice.
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KEYWORD
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Drug interaction, Phenytoin, Verapamil, Coadministration, Pharmacokinetic parameters, Dosage regimen
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